My research explores the mechanisms by which early-life ethanol exposure in rats, modeling fetal alcohol spectrum disorders (FASD) in humans, disrupts neurodevelopment and cognition (primarily learning and memory) across the lifespan. Our current work focuses on ethanol's nerotoxic effects on forebrain development, especially the hippocampus. As adolescents and adults, FASD rats are impaired in a variety of hippocampal-dependent Pavlovian paradigms, including tasks that require the bridging of two stimuli in time (trace fear conditioning) or the conjunctive encoding of contextual memories (context fear conditioning), both of which to rely on NMDA receptors within the the amygdala, hippocampus and prefrontal cortex. Our most recent research explores the relationship between postnatal ethanol exposure, neuroinflammation, and cognitive function. Specifically, we are pursuing the idea that ethanol induces long-lasting changes in the neuroimmune system, hindering later-life synaptic plasticity and long-term memory.
Experimentally, the lab utilizes a variety of neuroscience techniques, including behavioral assays, survival surgery (lesions, cannulae implants), neuropharmacology (systemic and local drug administration), neurophysiology (extracellular unit recordings), immunocytochemistry (IHC and IF), Western blots, and PCR.
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Goodfellow, M.J., Pochiro, J.M., Shin, Y., and Lindquist, D.H. (Submitted) Ibuprofen mitigates postnatal ethanol-induced neuroinflammation and ameliorates trace fear memory deficits in juvenile rats.
MacIlvane, N.M., Pochiro, J.M., Hurwitz, N.R., Goodfellow, M.J., and Lindquist D.H. (In Press) Recognition memory is selectively impaired in adult rats exposed to binge-like doses of ethanol during early postnatal life. Alcohol.
Pershing, M.L., Phenis, D., Valentini, V., Pocivavsek, A., Lindquist, D.H., Schwarcz, R., Bruno, J.P. (In Press) Prenatal kynurenine exposure results in age-dependent changes in NMDA receptor expression and conditioned fear response. Psychopharmacology.
Pochiro, J., Kaercher, R.M., and Lindquist, D.H. (2016) Amygdala-dependent increases in tone-evoked pontine nuclei activation accelerates auditory eyeblink conditioning in adult rats.Learning and Behavior, 40(2): 309-18. [pdf]
Goodfellow, M.J., Abdulla, K.A., and Lindquist, D.H. (2016) Impaired Pavlovian conditioning and altered hippocampal N-methyl-D-aspartate receptor subunit composition in a rat model of Fetal Alcohol Spectrum Disorders. Alcoholism, Clinical and Experimental Research, 40(2): 309-18. [pdf]
Dupont, C.M., Coppola, J.J., Kaercher, R.M., and Lindquist, D.H. (2014) Impaired trace fear conditioning and diminished ERK1/2 phosphorylation in the dorsal hippocampus of adult rats administered alcohol as neonates. Behavioral Neuroscience, 128(2): 187-98. [pdf]
Goodfellow, M.J. and Lindquist, D.H. (2014) Significant long-term, but not short-term, hippocampal-dependent memory impairment in adult rats exposed to alcohol in early postnatal life. Developmental Psychobiology, 56(6): 1316-26. [pdf]
Lindquist, D.H. (2013) Hippocampal-dependent Pavlovian conditioning in adult rats exposed to binge-like doses of ethanol as neonates. Behavioural Brain Research, 242: 191-99. [pdf]
Lindquist, D.H., Sokoloff, G., Milner, E.E., and Steinmetz, J.E. (2013) Neonatal ethanol exposure results in dose-dependent impairments in the acquisition and timing of the conditioned eyeblink response and altered cerebellar interpositus nucleus and hippocampal CA1 unit activity in adult rats. Alcohol, 47(6): 447-57. [pdf]
Lindquist, D.H., Steinmetz, J.E., Thompson, R.F. (2012) The cerebellum and classical eyeblink conditioning. In Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Rossi, F. (Eds.) Handbook of the Cerebellum and Cerebellar Disorders, New York: Springer Science.
Lindquist, D.H., Mahoney, L.P., and Steinmetz, J.E. (2010) Conditioned fear in adult rats is facilitated by the prior acquisition of a classically conditioned motor response. Neurobiology of Learning and Memory, 94: 167-75.
Lindquist, D.H., Vogel, R.W., and Steinmetz, J.E. (2009). Associative and non-associative blinking in classically conditioned adult rats. . Physiology & Behavior, 96: 399-411. [pdf]
Vogel, R.W., Amundson, J.C., Lindquist, D.H., and Steinmetz J.E. (2009). Eyeblink conditioning under an interstimulus interval switch in rabbits with a pharmacologically-disengaged cerebellar cortex. Behavioral Neuroscience, 123: 62-74. [pdf]
Steinmetz, J.E. and Lindquist, D.H. (2009). Neuronal basis of learning. In Berntson, G.G., Cacioppo, J.T. (Eds.) Handbook of Neuroscience for the Behavioral Sciences, (507-527): Hoboken, NJ: John Wiley & Sons.
Lindquist, D.H. and Steinmetz, J.E. (2008). Classical conditioning. In Darity, W.A. (Ed.) International Encyclopedia of Social Sciences, 2nd Ed., 9 vols., (pp. 572-75). Farmington Hills, MI: Macmillan Reference USA.
Lindquist, D.H. Sokoloff, G., and Steinmetz, J.E. (2007). Ethanol-exposed neonatal rats are impaired as adults in classical eyeblink conditioning at multiple unconditioned stimulus intensities. Brain Research , 1150: 155-166. [pdf]
Sokoloff, G., Lindquist, D.H., and Steinmetz, J.E. (2006). The effect of context and CS preexposure on acquisition of the classically conditioned eyeblink response in rats. International Journal of Comparative Psychology, 19: 398-416. [pdf]
Brown, T.H., Furtak, S. and Lindquist, D.H. (2004). Hebbian synapses. In Adelman, G. and Smith, B.H. (Eds.) Encyclopedia of Neuroscience, 3rd edition, , (CD-ROM). New York, NY: Elsevier Science.
Lindquist, D.H. and Brown, T.H. (2004). Temporal encoding in fear conditioning revealed through associative reflex facilitation. Behavioral Neuroscience, 118(2): 395-402. [pdf]
Lindquist, D.H., Jarrard, L.E. and Brown, T.H. (2004). Perirhinal cortex supports delay fear conditioning to rat ultrasonic social signals. The Journal of Neuroscience, 24(14): 3610-17. [pdf]
Lindquist, D.H. and Brown, T.H. (2004). Amygdalar NMDA receptors control the expression of associative reflex facilitation and three other conditional responses Behavioral Neuroscience, 118(1): 36-52. [pdf]
Brown, T.H., Byrne, J.H, Labar, K., LeDoux, J., Lindquist, D.H., Thompson, R.F., and Teyler, T.J. (2003). Learning and memory: Basic mechanisms. In Byrne, J.H. and Roberts, J.L. (Eds.) Cellular and Molecular Neuroscience, (pp. 499-574). San Diego, CA: Academic Press.
Brown, T.H., and Lindquist, D.H. (2003). ) Long-term potentiation: Amygdala. In Byrne, J.H. (Ed.) .) Learning and Memory, 2nd Ed. , (pp. 342-46).. Farmington Hills, MI: Macmillan Reference.
Choi, J.S., Lindquist, D.H., and Brown, T.H. (2001) Amygdala lesions prevent conditioned enhancement of the rat eyeblink reflex.. Behavioral Neuroscience , 115(4): 764-75. [pdf
Curriculum Vitae [pdf]
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