The hippocampus, a key brain area for memory function, changes dramatically in response to both beneficial and detrimental stimuli. Our lab focuses on the role of hippocampal neural stem and progenitor cells (NSPCs) in modulating the hippocampal response to environmental stimuli. We are especially interested in how the secretome of NSPCs can help define plastic versus pathological responses in the adult hippocampus.
Selected Publications
Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hoffree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. (2016). Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain. Molecular Neurodegeneration, 11, 31. PubMed.
Muroy, SE, Long, KLE, Kaufer, D*, Kirby, ED*. (2016). Moderate stress-induced social bonding and oxytocin signaling are disrupted by predator odor in male rats. Neuropsychopharmacology, accepted. *Co-corresponding author. PubMed.
Kirby, ED, Kuwahara, AA, Messer, RL, Wyss-Coray, T. (2015). Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche via secreted VEGF. Proceedings of the National Academy of Sciences USA, 112, 4128-4133. Direct submission. PubMed.
Castellano, JM, Kirby, ED, Wyss-Coray, T. (2015). Blood-borne revitalization of the aged brain. JAMA Neurology, in press. PubMed.
DeCarolis, NA, Kirby, ED, Wyss-Coray, T, Palmer, TD. (2015). The role of the microenvironmental niche in declining neural stem cell functions associated with biological aging. Cold Spring Harbor Perspectives in Medicine, 5, a025874.
Chetty, S, Friedman, AR, Taravosh-Lahn, K, Kirby, ED, Mirescu, C, Guo, F, Krupik, D, Nicholas, A, Geraghty, AC, Krishnamurthy, A, Tsai, M-K, Covarrubias, D, Wong, AT, Francis, DD, Sapolsky, RM, Palmer, TD, Pleasure, D, Kaufer, D. (2014). Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Molecular Psychiatry, 19, 1275-1283. PubMed.
Kirby, ED, Muroy, SE, Sun, WG, Covarrubias, D, Leong, MJ, Barchas, LA, Kaufer, D. (2013). Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife, 2, e00362. PubMed. F1000 Prime Recommended
Kirby, ED, Jensen, K, Goosens, KA, Kaufer, D. (2012). Stereotaxic surgery for excitotoxic lesion of specific brain nuclei in the adult rat. Journal of Visualized Experiments, 65, 4079. PubMed
Kirby, ED, Friedman, AR, Covarrubias, D, Ying, C, Sun, WG, Goosens, KA, Sapolsky, RM, Kaufer, D. (2012). Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons. Molecular Psychiatry, 17, 527-536. PubMed. Featured as cover image
Kirby, ED, Geraghty, AC, Ubuka, T, Bentley, GE, & Kaufer, D. (2009). Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats. Proceedings of the National Academy of Sciences USA, 106, 11324-11329. Direct submission with pre-arranged editor. PubMed Link.
Kirby, ED & Kaufer, D. (2009). “Stress and adult neurogenesis in the mammalian central nervous system.” In: H. Soreq, A. Friedman & D. Kaufer, eds. STRESS: from molecules to behavior. Weinheim, Germany; Wiley-Blackwell.
Glenn, MJ, Kirby, ED, Gibson, EM, Wong-Goodrich, S, Mellot, TJ, Blusztajn, JK, Williams, CL. (2008). Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain Research, 1237, 110-123. PubMed.
Glenn, MJ, Gibson, EM, Kirby, ED, Mellot, TJ, Blusztajn, JK, Williams, CL. (2007). Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. European Journal of Neuroscience, 25, 2473-2482. PubMed.
Kirby, ED, Williams, VP, Hocking, MC, Lane, JD, Williams, RB. (2006). Psychosocial benefits of three formats of a standardized behavioral stress management program. Psychosomatic Medicine, 68, 816-823. PubMed.